Last but not least, Highway 61 is another one that runs north-to-south rather than east-to-west. Connecting a small town in Minnesota to the electric city of New Orleans, Louisiana, Highway 61 is often referred to as the "Blues Highway" due to its many cultural stops having to do with blues and jazz music of the past. The route stretches 1,400 miles and can be completed in a week, but two weeks would allow for a more enriching experience, giving you the chance to truly take in all the sights along the way. Some must-see spots include B.B. Kings Blues Club in Nashville, the Rock n' Roll Museum in Memphis, Elvis Presley's Heartbreak Hotel in Memphis, and the Highway 61 Blues Museum to top it all off. So for every music lover out there, the "Blues Highway" route won't disappoint.