Historic Route 66 runs through the middle of downtown. There are themed restaurants, motels, and shops lining the road. A walking tour map is available at the Visitor’s Center. For young Disney/Pixar fans, think of the Cars movies. Radiator Springs in the movies and at Disney’s California Adventure is based on Route 66.
Lowell Observatory is where (former planet) Pluto was discovered. It is located on a hill in town. Flagstaff has laws limiting the use of outdoor lights at night so as to not interfere with telescopes. Evidence of an expanding galaxy, found here, helped lead to the Big Bang Theory. Although, this may sound dry, it is presented in a manner that is educational and quite enjoyable. Daily tours, video, lectures, and night-time viewing through the famous telescope are available.