Definately yes. The distance is hardly 150 km and you can easily book a self-drive ride with Myles and drive down to Chennai. Book a Myles car of your choice and get going. You can also opt for the smart km packages that allow you to pay only as much as it is required. Visit-https://www.mylescars.com/?gclid=EAIaIQobChMIz4TRycLr2gIV2IBwCh1OZA94EAAYASAAEgIS5vD_BwE
Yes it is possible but depend upon ur time which time ur starting from tirupati mode of transport : cab , Private bus , Government buses are Available cab will cost u high better to take private bus Like Volvo bus