So If you are planning a trip to Spiti valley in November; you have no other choice but to reach there via Shimla and return the same way. You cannot travel via Manali because Kunzum Pass would already have closed; and chances are the Rohtang Pass as well would have snowed out.
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In november you can but after Mid Dec Sometimes it will be closed fue to snowfall.
No you can't travel to spiti from manali but you can reach spiti via shimla