I've started my journey from Satara (which is about 900kms from Tirupati towards Pune) early in the morning by own car. you can go by bus or train also.. 2 nights 3 days are more than enough to explore whole Tirumalla city and near by places. 1) Kalahasti Temple - must visit for architecture. (avoid on holy days bcz of crowd) 7-8kms from tirupati hill entrance. 2)Sri venkateswara National park - Go for lions and crocodiles. 3) Chandragiri fort. all these places are in the distance of 25kms. stay at temple property only which will be more affordable..
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Bangalore has incredibly good bus services that provide entire package. You can check those out
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Go to chennai and then take a car ride or a taxi.. would be safe..