Seattle is a great place to see, and Portland, OR, is just a couple of hours south. But between Portland, OR and San Francisco is a 10hr freeway drive, slower if you take a coastal route.
San Francisco Bay Area - great natural beauty, great food, and cultural organizations, wine tasting.
Salinas - Museum devoted to John Steinbeck.
Monterey - great aquarium and scenery and a golf destination.
San Diego - World famous zoo and safari park.
Good Luck!! Happy Travelling!!