Naples is like a maze- a maze of cobbled streets peppered here and there with churches, restaurants, wine bars and tiny supermarkets. From never ending piazzas to the narrowest of alleyways coupled with art, history and a thriving food scene, this city has so much character to it that it could easily give Paris a run for its money. The locals are young, beautiful and full of energy and the pride they take in their cuisine is unparalleled, and rightly so. This probably could account for the numerous Pizza Marinaras and Pizza Margheritas one could easily gulp down without any sense of guilt whatsoever. Their Centro Storico is a UNESCO World Heritage Site and it is extremely difficult to keep track of the museums one can see because there are so many. Yet, you never get tired and neither do the pickpockets circling most of the city, so watch out!
You could take an InterCity/Regionale train from Rome and the ride is a little over an hour. Booking in advance on the Trenitalia website is a good idea. InterCity trains are faster and (Around 25 Euros one way) will give you reserved seats unlike their Regionale counterparts (11 Euros one way). For Regionale trains, make sure to validate your ticket on the several validation machines at the station just before you board the train.
Make sure you see Giuseppe Sanmartino's Veiled Christ (Cristo Velato) at the Cappella Sansevero near Dante. The marble veil over Christ is so intricate, so realistic that you almost want to lift it and fold it like an actual cloth. The wonderfully preserved human arterial systems on the lower floor are also worth seeing, although a little too macabre. Entry to the Chapel is 7 Euros per person and photography is absolutely prohibited.