The distance from Bangalore to Wayanad is 270 Kms approximately. The best time to visit Wayanad is in the month of July/August when the monsoon subsides, giving it a lush green panorama. I still remember the first time I went there, I fell in love with the beautiful tea plantation and trek to Chembra peak also called as the heart-shaped lake. There are many trekking opportunities in Wayanad if you are game for a little adventure.
Let me now jump straight to how my itinerary looks like:
Day 1: Start early, say at around 5 AM to avoid peak hour traffic. You could stop at Lokaruchi Kamat for a grand breakfast in a cozy set-up.
Once you reach Wayanad, take your time to settle in the resort of your choice (I had the opportunity to stay at http://www.vythiriresort.com/, which is a bit expensive but promises a glimpse of heaven). I always prefer to enjoy day-1 in the resort itself to do justice to the money I pay for accommodation, unless you are an avid user of bed & breakfast type places. The second time, however, I planned my stay at http://edakkal.com/, to ensure that I could make use of my Day 1 by walking up to the Edakkal caves close-by (for more details about them, visit http://www.keralatourism.org/wayanad/edakkal-caves-ambukuthi-hills.php).